Abstract: Countering the characteristics of high temperature and high mineralization in Shengli Oilfield, and in the view of device on polymer molecule, this paper introduces a new temperature-resistant and salt-tolerant pre-crosslinked swellable particulate which own both organic and inorganic system, the orthogonal method improves the fill prescriptions of pre-crosslinked swellable particulate. The result shows that the synthesis pre-crosslinked swellable particulate is not only temperature-resistant(120℃) and salt-tolerant(1.8×104mg/L),but also has many good synthesis functions which include high intensity,high adsorption,favorable heat stability and chemical stability.