Abstract: In company with the increase of water content, the cost of development is increasing too. In order to save energy and decrease the consumption, the pipeline with nanometer coating was used in this experiment. By means of the check experiment of different temperature and different water content, we know that crude oil was able to be transmitted in nanometer pipeline with lower pressure gradient and at lower utmost temperature. Because of its antisepsis, antiscale and paraffin control, it was suitable to be used in poor condition. Compared with common pipeline, its initial cost is relatively low, which makes it more advantageous. In a word, this kind of pipeline with nanometer paint has a good future.