Abstract: Wei79 fault block is a high pressure and low permeability reservoir.It is featured as poor reservoir physical property,small pore throat radius,high water injection pressure,poor water injection results,serious formation voidage,and not enouht energy,which lead to fluid supply not enough,and rapid production reducing.So the paper presents 6 new plug removal techniques.By using of multivariate plug removal technique,reservoir development indexes have been better improved.So it is a new comprehensive method for maturing period development of high pressure and low permeability reservoir.