Abstract: To address the issue of poor adaptability of profile control and flooding schemes in Bohai Oilfield due to the limited number of water injection wells and insufficient understanding of reservoir geology, this paper takes a typical block of Bohai SZ36-1 Oilfield as the research object. By establishing a geological model through numerical simulation, the sensitivity of injection parameters during the profile control and flooding adjustment process is analyzed using the grey correlation analysis method and orthogonal experimental design method. The results show that under different water-cut conditions, the sensitivity order of the three injection parameters to the increase in recovery rate as follows: slug size > concentration > injection rate. When the water cut is low (60%), the sensitivity order of the three injection parameters to the pressure increase during polymer microsphere flooding is injection rate > slug size > concentration. However, when the water cut is high (80% and 98%), the primary influencing factors for the pressure increase during both profile control and flooding adjustment are concentration > injection rate > slug size. In the real field dynamic adjustment process, the first step is to identify the key parameter that has the greatest impact on recovery efficiency, and then evaluate its sensitivity to the rate of injection pressure increase. If the sensitivity is strong, the second key parameter should be considered, and so on. The research results provide a scientific basis for the dynamic adjustment of profile control and flooding adjustment operations, which helps improve the effectiveness of the measures and the efficiency of oilfield development.