Abstract: To address the challenges of ambiguous seismic reflection characteristics of sand bodies and difficulties in fine reservoir characterization in Pinghu Formation reservoir of Baochu slope, Pinghu structural belt, Xihu Sag, which results from frequent sand-mud interbedding, rapid lateral variations, strong heterogeneity and superimposed coal seams, this study first implemented a systematic classification of the coal-bearing strata based on well-log lithological coupling characteristics. Subsequently, by comprehensively utilizing post-stack forward modeling, pre-stack forward modeling and pre-stack inversion techniques, a quantitative comparative analysis was conducted on the differences in seismic attribute responses and prediction outcomes of sandstone reservoirs before and after lithological replacement. The research results indicate that under the same conditions, the thickness of mudstone interbeds, sandstone thickness and the frequency of coal seam development are the key factors influencing the seismic reflection characteristics and prediction accuracy of sandstones. This research provides a theoretical basis and technical support for the fine characterization and precise identification of lithological target sand bodies in coal measure development areas.