Abstract: To investigate the impact of dry layer perforation on productivity of highly-deviated wells (horizontal wells) in low-permeability thin interbed reservoirs, the productivity ratio between dry layer perforation and dry layer non-perforation was derived by establishing a productivity mechanism model based on Borisov horizontal well productivity formula. Addtionally, a numerical simulation mechanism model was established to simulate the development performance of oil and water wells under both perforated and non-perforated dry layer conditions. The research results and field applications showed that for highly-deviated wells (horizontal wells) in low permeability and thin interbed reservoirs, partially perforating dry layers can increase the productivity to a certain extent, improve the development efficiency and reduce the development costs. The main factors influencing the productivity ratio are the vertical thickness of dry layer and the angle between wellbore and formation, while reservoir properties have little influence on this ratio. The findings of this study provide valuable references for the development of similar low-permeability thin interbed reservoirs.