With the development of a deep-water gas field, the wellhead of each production gas well has different degrees of uplift. The risk of well control is large, which destroys the integrity of the gas well wellbore and affects the normal production life of the gas well. In severe cases, the production pipeline may be broken, which directly affects the safe production of the gas field. Therefore, through the analysis of the influencing factors of gas well wellhead uplift, the wellhead uplift calculation model of multi-column coupling system of gas well wellhead device uplift is established, and the wellhead uplift height is calculated and compared with the field measured value. The results show that the temperature change of the string in the uncemented section is the main reason for the uplift of the Christmas tree, and the corresponding countermeasures and suggestions are given, which provides a reference for improving or solving the problem of wellhead uplift in gas fields.