In recent years, exploration and developing practice shows that the quality of seismic data which is the basic of pre-stack simultaneous inversion, directly affects the AVO characteristics of well point gather, the SNR and resolution of inversion volume. Therefore, improving the quality of pre-stack track collection in order to improve the accuracy of reservoir and fluid prediction should be the key process to pre-stack simultaneous inversion. By analysis of the quality of original gather, radon denoising optimization under well control has been carried out to improve the AVO reflection characteristics of the gather around the well point. The practical application shows that the reservoir prediction results are in good agreement with the actual drilling, and the reliability of sand body prediction has been effectively improved. This technology can be extended in reservoir prediction research.