Abstract: With the increasing development of low-permeability reservoirs in recent years, the requirements for accurate evaluation of reservoirs is becoming higher and higher. The Timur formula for calculating reservoir permeability cannot meet the needs of interpretation and evaluation. How to improve the accuracy of reservoir permeability calculation has become a major difficulty. This article analyzes the influence of sedimentary environment and diagenesis on physical properties of Wenchang formation in Lufeng depression zone, and extracts the sensitive factors related to permeability. On this basis, synthesizes core experimental analysis, geological and logging data, one permeability calculation model which based on lithological classification has been established. Good application results have been achieved in practical application, which provides a more rapid and effective way for accurately evaluating reservoir permeability.