Abstract: The upper U formation in N oil field develops delta front-shallow transition phase with siltstone and calcareous shale. The changeable sedimentary facies increased the difficulty of layer correlation. According to these features, combined with sequence stratig-raphy and seismic stratigraphy, integration of well and seismic was used to divide layers, under the control of seismic data and key bed, the formation isochronous framework was built. Then with the seismic reflection isochronism and the sedimentation cycle layers were divided in formation, 6 boundary interfaces of 80 wells was determined in research area. In the end, regional high-resolution se-quence stratigraphic framework was established, and senior stratigraphic framework technology in the accommodation space was formed.