Abstract: Limited by serious horizontal and vertical heterogeneity, Qiaokou oilfield comes across some difficults on waterflooding in low-permeability layers. Partition the layer into class I, II, III on the base of reservoir characteristics. The result shows that the recovery in layers class II, III will improve to 53.23% and 59.31% by proper exploitation technology on the basis of lab study on waterflooding recovery efficiency. A series of techniques are studied and applied to improve the recovery. Some big displacement directional wells & adjustment wells are drilled to solve the problem of heterogeneity. To solve the vertical heterogeneity of well section, the section adjustment of oil production & water-injection such as water shutoff, fracturing, divided-injection & augmented injection are applied. The practice at well site shows that the horizontal & verticle heterogeneity can be solved together with the increasing discovery. It also provides some experiences for the same type of reservoir.