Abstract: Taken Chang-2 reservoir in the Zhangtianqu oilfield as an example,it discusses the problems about the adaptability research of well pattern in low permeability reservoir. Calculated the range of reasonable well spacing density as well as relative interspacing and the reasonable injection-production ratio;By the method of numerical reservoir simulation,analyzed the problems existed in current well pattern arrangement in the Chang-2 reservoir. On the basis,summarized the common method of well pattern adaptability research of low permeability reservoir,pointed out the major non-adaptability factors in the Chang-2 reservoir in current. It has some reference value to the other low permeability reservoirs.