Abstract: It can remarkably reduce the friction between the rod string and the oil tube, improve the system efficiently and prolong application life of rod string and oil tube that rationally set the centralizer in the direction well sucker rod-pumping system. In this paper, the method of solving the value discontinuity of azimuth angle of the well is presented. The algorithm for the well orbit simulating using mouse interpolation is introduced. Using visual software, the centralizers can easily set by reading the setting data file or using keyboard and mouse input the setting data, and the setting result is displayed on the screen. Using the equivalent principle, the centralizer effect is equivalent to friction coefficient. Through computer simulation, the dynamic characteristics of the rod string such as the friction force and friction energy are calculated. The optimum system setting will be obtained with these data.