Abstract: When develop a low permeability gas-condensate reservoir, how to release from negative influence on gas well production caused by the appearance and congregation of oil condensation is always concerned by petroleum engineers. Based on the experiment and numerical simulation contrast of the effect of releasing the low permeability gas reservoir from retrograde condensation contamination by CO₂, N₂ and CH₄, this paper indicated that using the CO₂ would be a highly effective way to improve the development effect of a low permeability gas-condensate reservoir.