Abstract: Based on the comprehensive analyzing results of tectonic evolution and HC accumulation, the structure burial history, thermal evolution history, hydrocarbon generation, migration and accumulation history have been studied with basin modeling technology for Bozhong 21-22 structure of Bozhong sag in Bohai Sea area. Favorable exploration areas and hydrocarbon accumulation area have been pointed out. The study results indicate that during the sedimentation of Guantao Fm, source rock of Sha-3 and Dong-3 Members in Bozhong sag entered into hydrocarbon generation period, and has reached gas generation peak nowadays. Gas generat-edfrom Bozhong sag migrated through anachoric crust of burial hill and large unconformity surface into Bozhong 21-22 structure and accumulated in burial hill. Thus burial hill of Bozhong 21-22 structure is very favorable target area for exploration. The simulation results of hydrocarbon migration and accumulation have been proved by successful exploration in this area. Therefore, the hydrocarbon migration and accumulation simulation technology is an effective method for optimization and evaluation of favorable exploration area, and can decrease the exploration risk and increase the success rate of exploration.