Abstract: The low permeability reservoirs in Block Zhou 6 in Daqing Oilfield are poor in reservoir physical with low natural flowing production capacity.The stimulation result by regular fracturing is very poor.To solve these problems,the field testing has been conducted with multi-staged fracturing technique in horizontal well ZF1-P2.The point source limited perforation technique is used to infill fractures,and the fracturing operation for 15 fractured intervals has been completed with double-packer single-sticking fracturing technique in one-through operation with a pipe column.Through controlling accurately the volume of sand adding,sand-out fracturing has been finished.Fluid production after fracturing is 9.5 t/d,which is 6.3 times as much as that of other surrounding wells.The oil production is 8.1 t/d,which is 7.4 times as much as that of other surrounding wells.The fluid and oil production is 1.4 and 1.6 times as much as that of the horizontal well of the same block.The stimulation result and economic benefit is obvious,which provided practical experience for multi-staged fracturing in horizontal well.