Abstract: The petroleum exploration on the south area of East China Sea has lasted for more than 30 years. On the basis of the previous study results on this area for many years, it is believed that the hydrocarbon exploration potentials are great in widly spread Mesozoic sedimentary basins in this area. However, the target of previous study was at the Cenozoic strata, of which burial depth is relatively shallow. In addition, during the previous seismic surveys, some problems existed, for example, the streamer length was shorter, the volume of seismic source was smaller, and the depth of streamer and gun arrays was shallower. Accordingly, the quality of seismic profile was not good in deep strata. Through analysis on the previous seismic acquisition parameters in this area, the correlation of seismic profiles, the scenario for seismic acquisition parameters has been determinated. Through field testing, it has been proved that long streamer, huge gun volume and deep depth of streamer and gun arrays are beneficial for acquiring better seismic data of Mesozoic strata.