Abstract: In order to solve the borehole instability and sticking problems in directional well, horizontal well and high-angle well drilling, anti-sloughing lubricant FYJH-2 for drilling fluid was prepared. Laboratory and field application results show that FYJH-2 has strong inhibition, can significantly reduce the friction coefficient of drilling fluid, and has little influence on rheology and fluid loss performance of drilling fluid. It is also non-toxic and easily biodegraded which can meet the environmental requirements. As a kind of high-performance anti-sloughing lubricant, FYJH-2 has excellently performance to solve the problem of borehole collapse and drilling fluid lubrication which is suitable for deep well, directional well and horizontal well.